I did a quick playthrough my first go with the hood. Then I made a second character with a melee build (which is sick) to do the institute. Now I'm playing a survival run with a rifle/luck build. My advise, run another character with a totally different build. Do another faction and take it slow. Explore a little, do some side stuff and take advantage of the stuff you know about from your first run. Use your first character if you hear about some cool side stuff you want to check out (cabot house, saw maze, uss constitution, the murder house ect).