I choose to play Destiny 2 using the Windowed Fullscreen option so I can have easy access to my other monitors while I play. Every single time I launch the game through steam, the Window Mode option resets to Fullscreen, and you cannot access the Settings until you're completely logged in and in orbit. Bug has persisted for months at this point. Furthermore, other settings such as Chromatic Aberration and Motion Blur force themselves back on with each launch.
Also: Why does sound start playing on the title screen before the audio settings kick in? Every launch horns come blaring over my headset before my personal in-game audio settings take effect.
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You can try resetting your settings by deleting the cvars file. Instructions here: https://www.bungie.net/en/Help/Article/46407