There are some games where all I want to do is mute the in-game music and play some of my own tunes, but I don't think Destiny will fit that criteria.
Interestingly, this reminds me of a feature in Saint Row 1 where the in-game radios would play music saved on your hardrrive. While it wouldn't suit Destiny, I don't understand why it isn't put in more games.
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DMC to me had really cool and unique music