Playing through them in order is something incredible, with the Grand culmination of everything being a very important and traumatic part of me 3, which for me was the true end of mass effect as we knew it, it gave you a hint that no matter what you did, your story was coming to a close [spoiler]mordin[/spoiler] and even with the botched ending, and extended ending that imo made it worse, that situation was the end. I've never been more emotionally invested in a game or set of characters, and to be honest don't think I ever will.