I find the idea that people who are male/female born in a female/male body is quite disturbing. Something apparently went horribly wrong in development, or they're just mentally messed up. Either way, it's pretty sad to watch and it's clear they have a disorder. Maybe not mental like the APA says (as if it's relevant), but there's obviously physiological problems. Then again it could be mental as well if the patient just has identity issues.