So I Had the same issue in Beta and still has not been addressed. https://www.bungie.net/en/Forums/Post/230294478?sort=0&page=0 Originally I couldnt get passed the initial welcome to the game solo section without it crashing. Mostly happened when fighting/killing Paskh Seering Will. Tried: Rebooting Re-installing on a different drive Virus scanner completely off and destiny 2 as an exclusion (folder and .exe). Minimum Graphics Setting Maximum Graphics Setting High Graphics Setting G-Sync Off Moving from Display Port 144hz to HDMI 60hz Setup: Windows 10 64bit GIGABYTE AORUS GTX 1080 Ti Xtreme 11Gb 388.00 Nvidia Driver i7 4790k Stock 32gb ram Soundblaster Z ASUS ROG Swift PG279Q 27" - 144Hz G-Sync on DisplayPort The only way I could get through that bit without a crash was to run windowed (not full screen windowed) . Since then I tried going back to full screen and every other option but crashes still. So was not just that part in the game. Quite often it seems to be when water is near.... So try running Windowed mode with a resolution slightly lower than your desktop resolution and let me know if it fixes it... If not then try the same but with AA off.