Anyone who another person feels superior to.
Not as good at someone in pvp, you're a scrub.
Not as good at someone in PVE, you're a scrub.
Cheese the boss, you're a scrub.
Didn't cheese the boss, you're a scrub.
Got exotica from Xûr, you're a scrub.
Got exotics through random chance, you're a scrub.
Like Halo/CoD/Skyrim/Fallout, you're a scrub.
Have/don't have a significant other, you're a scrub.
Call someone a scrub, you're probably a scrub.