Never play on one save file, always have multiple and save at least every 15 minutes.
Bethesda games are notoriously buggy so if you end up with a corrupt save you can delete it and still have plenty more to fall back on. Saving regularly stops you losing too much game time.
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This is the second time I've had to redownload FO4, the game just breaks at times. Audio cutting out and sometimes I can't get any textures other then models to load until I hard reset my Xbox. I had the same experience in Fallout 3