Been depressed and anxious for years, medication never helped, if anything I think it made it worse.
Anyways what helped me was being self critical to an excessive degree. No point dying in self pity when if I put effort into getting out of my comfort zone I can be a bit happier. Probably a placebo thing, don't see how that could help my brain making dopamine or whatever.
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Some medications don't work, and can really -blam!- you up. I was lucky enough to find one that helped me, providing some stability while I reworked my shit. But yeah, you have to be incredibly introspective.