I am just going to cross post this from the other Fallout thread: [quote]Depends. What kind of build are you going for? You want to be a guns-centric player? A player who smooth talks his way through everything? A player who loads up on drugs on effortlessly slays everything with melee weapons? As for general tips: -Stay away from Cazadores and Deathclaws until you are a higher level -Intelligence is the best SPECIAL stat. The higher it is, you more skill points you can distribute per level -Don't put any points into Charisma. It only affects Speech and Barter, and some companion stuff. Useless -Reputations>Karma. Karma is less important in this game -Pick up items with low weight, yet high value. Carton of cigarettes are great in this regard. Easy caps -DLCs are great. Play them in this order though: Honest Hearts, Dead Money, Old World Blues, Lonesome Road -Explore! Many amazing pieces of gear and quests are off the beaten path -Don't fret too much about perks. Educated, Better Criticals, Jury Rigging are some essential ones though. I put them on almost every build I make. Here and Now, Swift Learner, In Shining Armor are all useless But really, just go into the game and have fun. Do whatever you want, ally with whoever, kill whoever, etc. Your next playthroughs can focus on maximizing optimal routes and builds.[/quote]