As long as Seth Green gets casted as Joker, then I don't care.
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And if they can, then they need to get all of the voice actors and actresses who do the aliens back to do their characters. Having anyone else voice Tali, Garrus, Wrex, Liara, Thane, Grunt, etc. is not something I'd find acceptable, I mean minor characters like Wreav or the Council or people like that I couldn't care less about, but the main alien characters should definitely have their voice actors from the game. And Martin Sheen has to play the Illusive Man of course :P