Seriously. I hate to repost, but here are my reasons:
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New Uncle Ben was a dick to Peter, and his death was anticlimactic. He never even said his signature line.
Mary-Jane wasn't even in it.
The new villain, Connors, was -blam!- compared to Osborn from the original. They even tried to pull off a schizophrenic thing where Connors talked to himself in the sewer. If you don't remember that, it's because it was stupid, and it was so much more memorable when Osborn talked to his mirror image in the original.
New Aunt Mae was too young.
New Peter was cocky, annoying, and too confident.
There were no memorable scenes or characters. And the animation was horrible when Connors transformed into the lizard.
Spiderman had his mask off way to much.
[i]More will come when I think of it.[/i]
[Edited on 08.08.2012 12:16 PM PDT]
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Actually i do think they used the great power with responsibility phrase, but reworded it. It was like "If you have the power to good, it is your responsibility to use it" or something.