I think this song from Bioshock Infinite sung by Elizabeth finally dethrones Ace Combat 4's "Megalith" and of course Halos soundtrack is basically in a league of its own...don't worry i am a huge fan :P.
Whats amazing is this is Elizabeth's voice actor who i don't think is actually a singer, her voice is amazing.
The feels...the feels.
More feels if you actually beat the game as well...
Also i figured this could both fit in off topic or gaming and i chose to put it in here.
-
The Mass Effect Trilogy. Best music in gaming, period.