I think I have a tie between Native Son and The Great Gatsby. I swear if it wasn't for Sparknotes and Google I would've failed my Literature classes. I never even read a single chapter of any of those novels.
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The Great Gatsby. To the above, The Great Gatsby was nowhere near 'good literature'. It was boring as hell. [Edited on 11.16.2012 6:13 AM PST]