Best overall roll is Inmostlight/Harmony.
You’ll have high ability and super up time in any activity.
I switch to Apotheo/Star Eater ahead of boss encounters to get orbs and have high damage.
Those are my main two rolls.
I also use Osmio/Verity for grenade builds.
Not really any roll worth taking off getaway artist for the way I play but if you're doing a lightning surge build, I like spirt of syntho to boost melee damage with spirit of assasin for invis. So you can lightning blink into a pack of enemies then be invis to run away from any retaliation
You want spirit of inmost light for ability uptime, and spirit of star eater for huge nova bomb damage. IMO these are universally good, every else is up to your preference.
Necrotic is fun for song of flame + melee spam builds. And spirit of apotheosis gives you several free grenades after your super ends. Assassin is useful for invis on warlock.
Everything else for the most part is niche or bad. Melt everything with swarmers, its the worst perk in the game.
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