Has happened twice while playing. mouse movement and input stops working in-game, but works fine when minimise the game. Only solution to this is to close the game and reopen it.
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03/10/2021 the problem is still there. is bungie going to fix this?
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I'm having this issues with my logitech mouse every now and then. If you have a wireless mouse, please try this: Plug your wireless receiver into pc but use the mouse with cable, in this setup is runs over cable. When your mouse stops working just pull the cable, then mouse reconnects over wireless receiver and might work again. It works with my G900. Please let me know if it worked for your and what mouse do you have.
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Happened to me twice some time ago during a Gambit match and other act I don't recall at this moment and have to close and open the game again same as you. Also a few days ago I was doing NF:Master with a friend and clanmate of him, and he had the same issue when we were arriving to the last door before the boss. He had to close the game and lauch it back.