After a win-one lose-one streak back to back over and over with a pal of mine in Mythic II, I literally got so tired up and angry that I soloed The Shattered Throne. I never planned to until that one night.
So tips for people!
1. Expect the unexpected.
You may have ran with others, but when you run by yourself, you have to watch your own back. Don't expect enemies to play nice either. They can be extremely aggressive (Taken Captains were my biggest fear) or super passive. Sometimes they'll stay near their spawn. Other times they'll chase you to the end of the frucking world just to deal that final blow, and that certainly is rage-inducing when they break their nature.
2. Be patient with damage and learning how to progess solo.
I'm usually an aggressive Guardian but there was no room for that in this cruel realm. You have to take your time with every single enemy. If you are unsure of what happens next, TAKE YOUR TIME. Rushing gets you killed, and you'll absolutely hate how far you get sent back. Though die as much as you need to adapt to the encounter/corridors/levels.
3. (88% of the time) LEAVE NOTHING ALIVE!
Doesn't matter if it's a shy Taken Thrall or a Hobgoblin that's sight is not on you. If you leave enemies alive, you'll regret it when you're back peddling from a critical hit. The first encounter is the perfect example. Even if random enemies spawn, kill them like they are truly a threat. Because every enemy is when they're armed with BS and a pattern-breaking nature.
To those still eager to try, all you need is Patience and Time. But we don't have the gun in D2 so patience and time will do. And a lot of Play of the Games. Just kidding, just do your best!
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This helped me so much. I was on a hunter but I still did it. It only took 100 tries on vorgeth