Is brawler even a positive modifier? Like really, unless you're going for a super specific build, why would you ever melee anything as your primary method of damage/killing?
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One-Two Punch. Titans (knockout, peregrine greaves, insurmountable skullfort, Synthoceps, Wormgod Caress) Ophidia Spathe + Knife Trick, Liar’s Handshake Empowered Melee, Arc Web melee. There are a lot of melee abilities/perks that get massive benefits from Brawler. I’d say brawler and grenadier are on pretty equal footing. Heavyweight is just so much better than the other two though.
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I think melee supers also get buffed by brawler
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If you're a hunter: Way of a Thousands Cuts + Ophidia Spathe. Infinite throwing knives if you get up to x3.
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Only with Peregrine Greaves Exotic boots. Skullfort works well too.