You're not alone, I've tried all the same things you have as well, nothing works. Between Steam, Origin, and Uplay I must have upwards of 100 games, most of which have been played on my current rig. Destiny 2 is the only game that gives me issues.
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Lend your voice! https://www.bungie.net/en/Forums/Post/249595962?sort=0&page=0 #D2BROCCOLIGATE