So, I use Right ALT for push to talk and always when I try to speak and I'm running in D2 my charachter slides so I checked the setting and Right ALT is apparently Control(Ctrl)...
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#Help
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You have a remap somewhere. To ensure you don’t have a remap in the game, you can delete your settings customization file (cvars.xml) following this process: https://www.bungie.net/en/Help/Article/46407 Remap might be out of game also, like with a gaming keyboard/mouse software. For instance I remap side buttons on my mouse to be specific keyboard inputs tied to health potions in Diablo - the same can be done on a keyboard with the right software.