Exactly the same here with a monster setup as well..... Had the same issue in Beta and still has not been addressed. https://www.bungie.net/en/Forums/Post/230294478?sort=0&page=0 Originally I couldnt get passed the initial welcome to the game solo section without it crashing. Mostly happens when fighting/killing Paskh Seering Will. Tried: Rebooting Re-installing on a different drive Virus scanner completely off and destiny 2 as an exclusion (folder and .exe). Minimum Graphics Setting Maximum Graphics Setting High Graphics Setting G-Sync Off Setup: Windows 10 64bit GIGABYTE AORUS GTX 1080 Ti Xtreme 11Gb 388.00 Nvidia Driver i7 4790k Stock 32gb ram Soundblaster Z 144Hz G-Sync on DisplayPort The only way I could get through that bit without a crash was to run windowed (not full screen windowed) with all settings on Low and no AA. After completing the initital intro part I putt it to Fullscreen Windowed and everyone on max and it was fine until a few missions in and started crashing again on the mission on the boat with big waves (can't remember what it was as I am at work currently :) ). Windows Event Viewer shows an Nvlddmkm Error (Display Driver Stopped Responding and Has Recovered)