There have been several occasions where as a BD, or just running around with a shotgun, I'll either stab them or shoot an enemy player, only to have them kill me shortly after, despite me clearly getting a hit marker with my shotgun at near point blank range and getting the melee off.
This is particularly common when I go up against Warlocks (with landfall or Nova Bombs) or the worst culprits, Titans and their Fist of Havoc.
I've lost count how many times I've lost against a Titan smash as a Blade Dancer, despite stabbing them 2-3 times with my own super or even using a shotgun/melee and somehow they either magically don't take any damage or escape with a sliver of HP.
Looking at the connections, nothing seemed to be really out of place, the bars were all green, so I'm not sure if it was really a latency issue. Netcode issue perhaps?
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They're not invincible, but some supers do give you a ton of extra armor. Some of them are next to impossible to kill (especially Fist of Panic).