So, I'm still forming my thoughts on Halo 5's campaign, but the plot points from Halo 4, 5, and other media leave some REALLY exciting possibilities.
How will the AI Assembly factor into the Reclamation? They seemed interested in working alongside humanity
If Cortana is defeated in Halo 6, she may need to be called upon and given authority in order to use the solution she talked about in Halo 3 to stop the Flood.
The Didact may need to be called upon by the Master Chief to stop the Reclamation. But will he remain an ally or take advantage of the opportunity?
Two Covenants will be formed in Halo 5, those pro-reclamation, and those anti-reclamation
Cortana talks about burning and reshaping those who oppose the Reclamation. She will Compose them.
The Domain has been revived. How and why? Precursors? Will the Domain's consciousness reawaken?
The Flood is adrift on the Spirit of Fire, heading back to UNSC-controlled space. They would ruin the Reclamation if they were to reemerge as a threat.
859 Static Carillon and Installation 03 are still missing.
The faction of pre-Covenant Sangheili living on the Refuge are still around with Enduring Bias. Will the refuge be used as the base of operations for the protagonists?
What will Mendicant Bias do/think about this, and where has he gone? Is he dead?
How will John's geas factor into this?
How will Genesis be used?
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Pre cursors come back and... [spoiler]imagine[/spoiler]