Tactics. And anything with high fire rate and decent TTK.
Last Word destroys Thorn in a 1-1 gunfight because it deals more bullets in less time. Pulse rifles do the same as long as you can aim yours. Get counterbalance, Hidden Hand, etc. on a good pulse rifle (or maybe even a scout with auto fire perk?).
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Thorn Deals 85 to the head With DOT deals 120 to the head With final round it deals 148 to the head A sniper body shot does about 151 damage (praedyths) tell me that shit isn't over powered. Timurs lash which has almost double thorns impact only deals 95 to the head as opposed to thorns 120 (dot) Timurs lash final round deals 126 thorns final round deals 148. Let that sink in. Copy and paste so people understand why it's over powered.
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Also, when you get tagged, don't just take cover. The tick marks still give you away and you won't have the health to sustain a grenade. Better to back right out and take an alternate route back in. When I use Thorn, I get hammered to death by fast guns, rush tactics, and shoulder charges. Don't try to close in from a distance with a shotgun though; I only say rush if it's already become a sort of "surprise" close-in engagement. Shotgun's an all or nothing gamble and you've probably already been clipped twice before you get in range.