It would have to have matchmaking. Trying to put together 11 other people together would be a struggle. Then it would have to be something w/o mechanics (if there was any they would have to be easy). I think it would be best used in like a defense-type game mode where you survive wave after wave...
[spoiler]...slowly driftin'...[/spoiler]
...defending the Tower wall. Like 10 waves or so for loot.
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Dude. In WoW they had to put together 25 man raid teams lol.
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I know. In FFXIV they had 24 team stuff too. But you gotta think that they have chat boxes because they're on pc, so they could communicate strategy/plan. Not everyone uses a mic on xbox/psn, so it would be hard for them. Plus WOW and FFXIV have better matchmaking techniques and such.