I love the Titan class, specifically the Striker class.
The set up that I currently run is like so:
Molniya Type 2 (Mentor gear)
Willbreakers Fist
The Armamentarium
Molniya Type 0
Primary weapons: Badger CCL, Red Death, and Mida Multi Tool
Secondary: Y-09 Longbow Synthesis, Ice Breaker, and Secret Handshake
Heavy: Gjallarhorn, One Way Ticket
With the Armamentarium allows me 7 rounds for the Ghorn and an extra grenade. The bonus grenade is like a get out jail free card. And the extra rounds for my Ghorn? Forget about it.
I play the Defender subclass in situations where everyone knows what they're doing and can benefit (by benefit I mean I actually use) the bubble of goodness OR when I'm raiding and am the only Titan in the group.
As the other two have stated, Titan's can take a few shots, so sit back and use your Sniper rifle. Don't confuse the idea of being a "Tank" with the need to rush through everything seeking only carnage. Take your time, make your shots count. Then when you need to clear things out, pop a grenade, slap the ground, and watch the death pile up.
English
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My Titan's my main, though I might not be using her to her full potential. Helm of Saint-14 Blinds all beings that wander in. Pop it on a tight group of enemies in PvE and go all Rocky on them or in PvP, it plus Shotgun on Control is guaranteed murder and mayhem. Also, I REALLY like sticky grenades. Stick and forget. Striker...I mainly play control, so my main suggestion is to use the smash when the enemy is trying to take a point with multiple people at it. Triple Kill Nail in the Coffin is a great feeling. But yeah, my K/d is .81, so take this as you will.