I would have to say my all time favorite is Eureka 7, followed by Clannad. What's yours?
edit 1: holy crap over 1000 replies! I see we have tons of otakus here. Haha! Keep it up!
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Pinning a favorite on an anime is impossible for me. But out of curiosity I'd like to see some waifus. Mine is shiina mashiro http://i.imgur.com/0WOEIkp.png