https://www.youtube.com/watch?v=JCv53TK4YGk
I got 130 Spirit Blooms in around 45 minutes last night and I know for a fact I might've missed some chests and or spirit blooms, which just means it would have even been more than 130!! I feel like this could easily be the best route around, but am always always willing to learn new spots. ALL CREDIT GOES TO MY BOY GRINDIN for showing me this spot!!
https://www.youtube.com/watch?v=JCv53TK4YGk
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There's another spot that pays out even better. It's the spot on eye of a gate lord, where you activate a conflux guarded by three minotaurs. Pulled 130 in an hour this morning plus many chests and plenty of yellow minotaurs to level up on. Also, I farm there during the mission I listed. Just seems to spawn faster bloom. Run a counter clockwise circle starting at the cave behind the conflux and ending there. Great profitable route.