https://www.youtube.com/watch?v=JCv53TK4YGk
I got 130 Spirit Blooms in around 45 minutes last night and I know for a fact I might've missed some chests and or spirit blooms, which just means it would have even been more than 130!! I feel like this could easily be the best route around, but am always always willing to learn new spots. ALL CREDIT GOES TO MY BOY GRINDIN for showing me this spot!!
https://www.youtube.com/watch?v=JCv53TK4YGk
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I really get these with ease, it's so bad that I have tons sitting in the vault and that was without farming for them. Farming can easily get old fast but then this game is getting old fast. I personally feel that they should have a long respawn timer, same for helium filaments; you'd figure that they learned from the loot cave.