Move into the little ones where the taken are, then move out and shoot the -blam!- outta the big ball. You get a few seconds before you have to repeat the process. Something has a countdown on your screen giving you about 5 seconds of damage to it.
If you have Wardcliff Coil, use that and it'll only take a few shots.
Big thing appears once you've hit the big thing enough, so wipe the floor with it.
A video:
https://www.youtube.com/watch?v=y3dQtmItTaQ
English
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Nice explanation. Thank you
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Make the Blight teleport once or twice beforehand. It lowers the health of the blight so you won't have to shoot it as much than when it has just spawned.