So it surprises me that when people start the discussion of what they would like for D2, hardly anyone (that I've seen) says, "Hey, let us program the d pad so that we can pop heavy synths during the heat of combat" or "give us in game loadouts like COD that can be selected during respawns". It's SO damned clunky to have to start, wait for your inventory to load into the GUI, then select your item...all the while your screen has a flashing red border that means while you're doing something that's crucial to your contribution to your fireteam, you're getting your ass kicked. That's what I'd like to see most of all; faster equipment swaps and consumption of buffs via a simple button press.
Edit: Thanks to everyone who has replied with constructive input and counterpoints. Mostly, though, thanks to everyone for keeping it civil.
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Tap d pad for emo/dance hold in for ammo.