As a PvE-er, I'd say that they're completely overshadowed by voidwalkers. Why have fist of havoc when you could have a ranged fist of havoc, which is safer.
[i]*proceeds to take self damage from nova bomb*[/i]
Okay, fair point. But voidwalkers also have the energy drain build. What do strikers have for PvE? Nothing but a good time with the Peregrine Greaves.
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Transfusion shoulder charge