Personally, I think that hobgobs are, without a doubt, my most hated enemy.
Unless slain with pinpoint accuracy, and even then do they not always die from a crit shot with my trusty Fatebringer, will you dismiss them quickly, before they do their little mini-radiance-shield-bubble-fire thing.
Vex minotaurs no longer are my most hated because.... Well, because Swordbreaker.
Which enemy leaves you frustrated upon sight?
How do you decimate that yellow bar of HP?
Let me hear you, guardians.
Edit 1: Wow, 350+ replies in about 24 hours. I'm glad others share a hatred for a certain enemy, and the mix of replies being posted below certainly are comical. Thanks for posting!
Edit 2: we busted up through 650 replies. Didn't see this coming but it's still quite entertaining to see everyone's thoughts.
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Edited by Beeburrito: 6/25/2015 3:00:16 PMButter bar wolf captains in 35 PoE. Same goes for the servitors.