Well some of the exploration quests would actually spawn a mini boss you had to fight in certain areas, so honestly I wouldn't be surprised if they had something at least similar to this. If not, I'm sure they can incorporate it fairly easy. Though to make it really worth it, and create cool exclusive gear like that, it would have to be quests you could only obtain perhaps after you built your allegiance with certain factions up for a while. Still a cool idea.
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Now thats a great idea. Like the bounties you could buy a mission from factions after you reach a certain rank with them, the mission would not be repeatable for 1 week to prevent farming. Their could be different tiers of missions as you get higher faction ranks.
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I really hope they do something like that. The more variety of PVE end game content, the better in my opinion!