Invisibility works great in PvE, but that's because the enemies are programed to ignore you. In the few instances where I can view my character in third person i'm not really all that invisible. Even when standing completely motionless you're still quite blue. I've tried using it in the Crucible and i'm being spotted almost instantly regardless.
Is there any practical use to trying to use invisibility against real flesh and blood players with eyeballs or should it just be ignored in favor of other skills when in PvP?
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Yeah, if you feel the need to rely on a crutch that only your class has. Other than that, 1) It's not good. 2) Only the oblivious won't see you. 3) You're bad if you have to rely on it.