SPOILERS
I mean cortana's demise on halo4. Is she really dead?. I know you guys have better understanding of the halo universe than me.
Do you tuhink she will ever comeback?
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I think it would be pretty deluded of 343 to kill a main character off in the first game of a trilogy. And personally No Cortana =/= Halo. I think it is pretty certain she will be back, considering they hyped her up being this purposefully seeded ancilla, if they then U-turn and just kill her off I will be laughing for ages.