For me at the moment, It's Kirin. It carted me twice and then I started dealing zero damage to it. After that I just quit the quest, because it seemed like I wasn't ready to take it on yet.
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The zero damage is when it buffs up and it's mane gets ridiculously tanky. Hit the face if you can. But yeah, Kirin is tough
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Elderseal weapons if ya can. Or the dragon pods that go in the slinger.