Hand cannons are still the best primary, but there's definitely some noticeable changes.
Thorn can't quite snipe like it used to, and neither can TLW. Shotguns are pretty much balanced now, and Shoot to Loot got fixed which is absolutely amazing.
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I've been having no issues sniping with thorn.
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Oh, you can still land your double headshots from pretty far out. You just can't beat snipers with it at long range any more, even with Send It the shots are too inaccurate.