Okay so this is Jan 6th 2021, I've been having this issue for a while and I wanted to try and help some people as I've done a bit a research, turning steam friend to offline still absolutely helps, in my case it did but it didn't resolve it, I only have 3 friend on steam either way, still would recommend trying it. graphics setting do not matter, I used low settings as a base line and it still happened then. I even got a new mouse because I kind of cheaped out on one and thought it might be polling(Was not the mouse). what did work was turning my monitor to 60 hertz instead of 144, that did wonders, its gonna feel terrible for a hot minute if you were playing on 144, but you get used to it. TLDR -Turn steam friends offline -Turn monitor to 60Hz Build -Ryzen 7 2700x -Asus x570 plus wifi -Corsair vengeance 16gb -2 Sk Hynix SSD's( one M.2 and one 2.5) -Power color 5700xt