Lower the difficulty setting from average to very easy. I do this on casual playthroughs because the only benefit you can reap is more xp the higher the difficulty setting. A 357 revolver is a good starter weapon. 44 and ranger sequoias are very good as well, although sequoias are harder to attain. Get some good armor, like leather armor is good for starters. You can get some easily. Put your strength amd luck to 10. You do not need charisma or perception or intelligence. Since this is your first playthrough, vats is very useful. So high agility might help as well on a first playthrough. If you see a deathclaw, run. You arent ready yet. Get the wild wastlander perk. You get the best weapon in the game. The alien blaster. Look up where to find it. And lastly, take. Your. Time. Do not rush the game. Just explore everything.