I don't necessarily think that vehicles would really be a good addition to Fallout 4, it would cut back with exploration. But maybe something like a Brahmin train or a mutated horse.
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True. If they could make a large enough map for vehicles AND in-depth close-proximity exploration, that would be fantastic.
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Maybe if they had an old beat up, weathered motor bike that took 10m/g then it might work. The only problem is there is no oil in the Fallout universe, it all dried up after the Resource wars witch in turn led to the Great War.