I had a hell of a time trying figure out what was happening in Crysis 2 seeing as how I didn't play the first game.
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The first game doesn't have much to do with the second game aside from the setting. The first basically established that aliens were attacking, we were at war with North Korea, and there was powered armor. The second dropped the North Korea thing entirely and had only one main plot tie to the first game in the form of Prophet.