As the title, this has been asked many times. It was of course part of it originally when the perks were armour mods and all could be unlocked so your mod setup was in your loadout. Ever since it changed to the 12 selection setup it has been incredibly annoying that whenever I make a loadout switch or change to an activity that needs a different artifact setup I need to manually change each one and of course remember which were needed for what each time. Just to make it clear not asking for them all to be active. Your loadouts should store and apply your selection of 12 per loadout.