In most (like 95-98%) cases I would agree with you. There ARE however some pretty special perk combinations out there that truly do make a difference in at least in pve. They are very rare, so this doesn't apply to the vast majority of weapons put there A few examples off the top of my head: Osmosis + demolotionist Kinetic tremors + shoot to loot Adaptive munitions + turnabout Chill clip + autoloading holster destabilizing rounds + repulsor brace Still waiting for a weapon that can roll with gunshot straight and a payload perk- kind of a long shot but that may have some fun synnergy in the right situation depending on how they work together