I think they share some similarities, but mass effects world is so much bigger and on a bigger scale, and much much more diverse , I cant even count all the different species in ME , and each one is different and unique and has there own lore and culture , Bungie has hinted at other species , but doesn't want to do the work to put them in the game, Rhulk is the first real new species we have had in 8 years, and all we know about him is the name of his planet and he really likes the witness. And Bungie is just now starting to flesh out the Eliksni and Cabal , and have barely brushed upon the Vex But if I were to make some comparisons Cabal/Krogan ---‐---------------------- Physically imposing species renowned for there military prowess, value honor and bravery above all Taken/Reaper Forces --------‐------------------ Husks of other species being used has ground forces by the main antagonists Spectres/Guardians --‐---------------------------- Seen has the most elite soldiers in the universe , equally respected,praised and feared Eliksni/Quarians -------------------------- This one is a bit of a stretch, but they both value technology, and incorporate there biological bodies with synthetic tech , and they are both looked down upon but for vastly different reasons Asari/Awoken ---------------------- Both Humanoid Matriarchal society's, I actually have head canon that the protheans created the Asari from an ancient female human, both are naturally gifted Lightbearers/Biotics -------------------------- Wielders of space magic That's really all I can think of right now, The Reapers are like a combination of the Gardner and Winnower, They take life , but they also seed new life for the next harvest , and Mass Effect is not just shooting and space magic, it asks the player questions , Species superiority, the validity of interspecies relationships, does Synthetics have a soul, population control and alot more If you just skimmed over this, I will say Mass Effect is Star Trek , and Destiny is Star Wars