I think it depends on what you prefer.... Post apocalyptic, radiated junk yard or dragony, cool as -blam!- armor gamestyle.
They both sort of play the same obviously. Pick up any and everything, loot, sell, trade, craft, scavenge, kill. repeat. Oh, and buy/decorate your house lol.
I actually like both. Both have different things that appeal to me and both are cool to dick off and spend hours playing.