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They do, there's a build for titan that'll cause knockout on arc classes to ohk punch anyone for as long as they keep it proc'd and a hunter build that gives an almost invincible overshield while they're dodging (I know the hunter one as I tested it myself and my god the artifact is wack)
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It does, if you use the titan's magnetic grenade on the void class with oppressive darkness it will proc the weakness upon sticking and the 2 detonations will be affected by the weakness and kill the victim.