As long as they can hold their own in a gun fight and don't do anything stupid (such as throwing up a ward of dawn directly where the relic holder is standing while fighting Atheon) I have no problems. I find myself limited on what games i am able to play with them though not because they are girls but of what other guys will do when they hear them. A couple days ago I was doing the VOG and this one player was having trouble with the jumping part. They hadn't been talking the entire game when suddenly their mic turned on. It was a girl and within ten seconds i watched 2 players jump off the edge (suicide) to come to her aid (white knights) while the other two commenced with the kitchen jokes. She quit about thirty seconds later. I rolled my eyes and went back to orbit myself. What should have happened is we should have let her learn it on her own or one person should have gone up to help her while the rest of us waited below or tried to explore new areas. I guess what I'm trying to say is as long as everyone acts polite and professional i don't care if you are a guy or girl. Just play the game, kill stuff, and have fun doing it.