I don't have any friends to play Destiny with, will I loose a large part of the experience since I will probably have to lone wolf most of it?
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My suggestion is to find and join one of the numerous clans popping up on this site. it can be intimidating at first, but eventually you'll find a core group and have a blast. IMO you DO lose something by solo-ing, unless you prefer the lone wolf approach, in which case god-speed and have fun!