AMD put out a new driver 21.1.1 and while it did not resolve the issue it did change the HWinfo64 results. Each run was done running around killing things in Tangled Shore after patch 3.0.2: 21.1.1 Shader Cache Off + DXcache cleared https://imgur.com/gallery/02NMk9q 21.1.1 Shader Cache On https://imgur.com/gallery/A1Bw0gK 21.1.1 Shader Cache On + Multi Threaded Render 1 CVAR edit. https://imgur.com/gallery/WB2J1WM DXDIAG: https://pastebin.com/GikH1Q9n As you can see Shader Cache Off does not seem to help, however editing cvar does. However keep in mind the cvar edit is unusable as a fix as there are horrible flickering textures. There are [b]no issues[/b] when I swap only the GPU to an Nvidia 1080, same system (POST 3.0.2)